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It is generally accepted that in vitro studies with concentrations of active compounds beyond the IC50 concentration of 25 M for pure compounds and the IC50 of 100 g/mL for the extracts have no therapeutic significance because they could not be implemented in vivo and are not appropriate for further pharmaceutical development [272]

Using expired reconstituted tirzepatide carries all the same risks discussed above, plus additional contamination concerns if the bacteriostatic water preservative has degraded

The compound sits in a kind of academic limbo, well-known in the nootropic community but largely abandoned by mainstream pharmaceutical research

For some genes, the Broad Institute database gives more than one value and they are averaged in the tables

doi:10.1146/annurev.pharmtox.45.120403.095857