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doi: 10.1038/cdd.2014.150 15 GuYHanJJiangCZhangY

Modelled on a fragment of the naturally occurring pineal peptide complex epithalamin, Epitalon (also written AEDG, after its amino-acid sequence) is a synthetic tetrapeptide that has become a central reagent in the study of cellular aging

These agents help the liver break down and transport fat , prevent fat accumulation , and support methylation , a key biochemical pathway for detoxification, mood balance, and DNA repair

Oxidative stress, induced by ROS, triggered the translocation of Fas into lipid rafts, the formation of a Fas-associated signaling complex, and the subsequent activation of caspases-8 and -3

The logic of this cascade is elegant in its simplicity and compelling in its clinical implications