Research output: Contribution to journal Article peer-review The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFBp50 Munanairi, A., Rudnick, D
Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)
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Indeed, redox balance can be the cause or consequence of a disease, and in some cases, it is difficult to know the level at which an antioxidant becomes a prooxidant
In this study, mixed amino acids upregulated the expression of HO-1 through the activation of Nrf2 in HepG2 cells and effectively inhibited ethanol-induced oxidative stress (Figure 7 and Figure 8)
