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Hsieh MJ et al

Aptamers, being composed of nucleic acids, have negatively charged phosphate backbones

Abstract Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that imposes a substantial disease burden, globally

Just before administration, the soluble powder and oral solution were prediluted with water for injection to facilitate gavage administration

However, decreased responsiveness to VIM DBS by select body parts (possibly due to the somatotopic organization of the VIM nucleus) increased tolerance to VIM stimulation due to compensation or disease progression [176, 177], and the development of adverse side effects, such as dysarthia and dysphagia [174], in patients, has driven efforts to optimize DBS targeting