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Modulation of MAPK & JAK/STAT Pathways By inhibiting MAPK14 (pro-apoptotic) and activating JAK/STAT3 (pro-survival), PQQ balances cell proliferation

Cells drop into senescence in increasing amounts as we age, and its one of the leading theories on why humans grow old and die eventually, the number of cells that are dividing and renewing the body drop in proportion to the number of cells in senescence, leading to higher and higher numbers of dysfunctional cells (that can cause cancer or inflammation), and the human body degrades until it can no longer function and we die

Michele Green is a board-certified cosmetic dermatologist and specialist in melasma and hyperpigmentation

PLoS One, 2010

PLoS One 20 , e0322479 (2025)