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Subcutaneous injection near the abdomen targets gut-related effects more directly, while oral peptide capsules offer an alternative delivery method that directly contacts the GI mucosa

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The precise regulation of ALS pathogenetic mechanisms is still elusive, despite the abundance of identified mechanisms mediating MN degeneration and death, including neuroinflammation, glutamate excitotoxicity, altered RNA metabolism, mitochondrial dysfunction, impaired cytoskeletal integrity, altered axonal transport dynamics, OS [71, 84, 85]

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