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the aggregating alpha-synuclein also binds preferentially to mitochondria where it can disrupt energy metabolism leading to oxidative stress

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The primary application evaluated for these biomarkers would be to increase the specificity of PSA and thereby reduce unnecessary biopsies (186188)

Monitoring: Regular clinical follow-up ensures any adverse effects are detected early and protocols are adjusted accordingly

For animal toxicological studies, although there were more data of higher quality available, few endpoints (ie, auditory function and ototoxicity) were investigated for the same type of jet fuel across the various studies