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Future research should prioritize high-quality trials to evaluate mitochondrial-targeted interventions, validate redox-based biomarkers, and optimize treatment protocols for improved patient outcomes

J Immunol 201:13431351 Singh RP, Grinenko T, Ramasz B et al (2018) Hematopoietic stem cells but not multipotent progenitors drive erythropoiesis during chronic erythroid stress in EPO transgenic mice

Understanding these differences helps in selecting the appropriate delivery method for specific goals

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)