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GSH was associated with cell-cycle activation in cell suspension cultures, whereas hGSH was associated with differentiated cells ( Although all mutant nodules exhibited a distinct thiol composition, the GSH:hGSH ratio correlated with the extent of infection (Supplementary Table 2)

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(2013) The chemistry and biological activities of N-acetylcysteine

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Clinical experience with PRLX93936 underscores the ceiling for systemic dosing, as a phase I trial was terminated early when patients experienced severe, intolerable toxicity at very low doses (93), revealing an exceptionally narrow therapeutic index