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Increased iron uptake occurs through upregulation of transferrin receptor 1 and divalent metal transporter 1, coupled with impaired iron export and storage due to reduced expression of ferroportin expression and dysfunction ferritin buffering [205, 206]

The procedure often takes less than 30 minutes, and patients are typically advised to rest from strenuous activity for 24 hours following an injection

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The 150,000-GSF facility is designed to maximize flexibility, as 20,000 GSF of open research laboratories flank 20,000 GSF of central laboratory core, including common equipment rooms, specialty labs, micropsy, tissue culture, imaging and glasswash divided by a central service corridor on the two upper floors