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The manufacturer (EMD Serono) voluntarily discontinued Geref in 2008 for commercial reasons, not due to safety concerns

Synephrine and octopamine may be present in small amounts in legitimate citrus extracts such as citrus aurantium or sinensis

Tauopathy is characteristic of the major neurodegenerative disease, Alzheimers disease (AD) [349], where tau protein is aberrantly hyperphosphorylated and forms bundles of filaments [350]

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The changes in GSH levels induced by such stress are instantaneous and drastic processes, while the generation and replenishment of GSH require a lengthy process, due to involving the rate-limiting indicator glutathione synthetase [43]