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The structural designs of all pipeline antagonists are schematically illustrated in Fig

Indeed, ROS production may promote the activity of RIPK1 or MLKL in necroptosis induction

Members of the monomeric G-protein Rab family, specifically Rab8a, Rab13, and TBC1 domain family member 4 (encoded by the TBC1D4 gene) have been shown to be critical to the insulin-stimulated mobilization of GLUT4 to the plasma membrane in skeletal muscle while Rab10 is involved in the process in adipocytes

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