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doi: 10.3390/ijms21113847 59
Nitric oxide inhibits the transcription repressor yin-yang 1 binding activity at the silencer region of the fas promoter: a pivotal role for nitric oxide in the up-regulation of fas gene expression in human tumor cells
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However, lactate levels can increase up to 10 mM in inflammatory pathologies (for example, rheumatic synovial fluid) 48
Animal model: Protection and repair of intestinal epithelial physical barrier by IGF-1 LR3 Animal models are closer to the physiological environment in vivo and can comprehensively evaluate the impact of IGF-1 LR3 on the physical barrier of intestinal epithelium
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