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In addition, GCs inhibit the proliferation of osteoblast precursors via suppression of intracellular mitogenic signaling pathways, specifically mitogen-activated protein kinase (MAPK) signaling [25, 26]

Conversely, in lung and breast cancer, elevated CHAC2 correlates with advanced tumor stage and grade, indicating a worse prognosis (Liu et al., 2017

Lipid metabolism and lipid droplets Mitochondrial dysfunction impairs -oxidation of fatty acids, leading to lipid droplet accumulation within astrocytes

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Hsieh 2017), describes a coordinated effect on vascular and fibroblast biology