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Glutathione reductase (GR), which catalyzes the reaction NADPH + GSSG + H+ NADP+ + 2GSH, plays an important role in the maintenance of cellular oxidant status (15)
One-Carbon Metabolism in Health and Disease
Simvastatin was found to significantly diminish the processing and presentation of tetanus toxoid to CD4 T-lymphocytes by preventing protein antigen uptake via receptor-mediated endocytosis and macropinocytosis, again secondary to defective prenylation by Rab and Rho GTPases (Ghittoni et al., 2006)
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