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doi: 10.1021/acschemneuro.2c00580 116 YanH.QinQ.YanS.ChenJ.YangY.LiT.et al

As the disease progresses, additional brain regions involved in higher cognitive functions are affected, leading to more widespread cognitive and behavioral impairments ( 4 Biochemical and molecular mechanisms in PD Parkinsons disease is a chronic neurodegenerative disorder that is also progressive, similar to AD, and mainly affects the motor system, though non-motor symptoms are also prevalent