However, the increasing ratio of GSH/GSSG in response to exogenously applied melatonin showed the beneficial effect of melatonin in reducing oxidative stress and improving water stress tolerance, in line with the research reported by Galano et al
Mutation of C8, C26, or C83 conferred protection against the PSSG-mediated decrease in activity towards diE-GSSG, yielding activities that were not statistically different from the respective controls
Usually, the best results are achieved with 10 to 12 treatments spaced 6 to 8 weeks apart
This transcription factor participates in the protection of cells against oxidative stress by upregulating the expression, among others, of genes involved in the antioxidant GSH pathway [39,40]
Studies suggest it protects nerve cells and may reduce risks linked to neurological conditions like Parkinsons or Alzheimers