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8 Findings from current studies of APAP hepatotoxicity seem to favor the mechanism of toxic injury being related to mitochondrial and endoplasmic reticula leading to hepatocyte injury and necrosis

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Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression

Human studies Five human studies investigated the effect of specific diets/nutritional programs on ES-induced outcomes