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doi: 10.1016/S1087-0792(98)90020-X 45 HardelandRPoeggelerB
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
Risks include nausea, cardiovascular effects, priapism (prolonged erection requiring emergency care), skin changes, and unknown long-term effects
[DOI] [PubMed] [Google Scholar] Chen H
(NPR reached out to Noah Jay through his TikTok and Instagram accounts for comment and to ask if he receives any income from the peptide sales, but did not receive a reply.) But there are risks when using substances that aren't approved by the Food and Drug Administration for human use
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