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By the time most patients are in their late 30s or 40s, pineal calcification and reduced melatonin synthesis have already begun degrading sleep architecture, particularly the slow-wave deep sleep phases where cellular repair, growth hormone release, and memory consolidation occur

Chinta SJ, Kumar MJ, Hsu M, Rajagopalan S, Kaur D, Rane A, Nicholls DG, Choi J, Andersen JK (2007) Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration

J Med Chem 38:272276 Pothula SP, Xu Z, Goldstein D, Pirola RC, Wilson JS, Apte MV (2016) Key role of pancreatic stellate cells in pancreatic cancer

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