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67 In line with a role of ATII in endothelial dysfunction and hypertension, numerous studies have now demonstrated that the therapy with angiotensin-converting enzyme inhibitors and AT-1 receptor blockers is associated with an improvements in endothelial responsiveness 68, 69, 70, 71, 72 (the existence of negative reports also needs to be acknowledged)

The second clue was the fact that glutamate receptors are really dense in dopamine-centric areas tied to schizophrenia (so dopamine was a knock-on effect)

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& Walker, C

Santavy failed at that one, too