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The antibody fragments are displayed on the surface of filamentous bacteriophage (M13)
which is important for controlling the level of reactive oxygen species (ROS)
selective for GLS1 over GLS2
2230Da) of 24 amino acids linked by 5 intramolecular thioether bridges
The endoplasmic reticulum (ER) is a significant membranous structure that bridges the nuclear membrane and the plasma membrane
IL-36α (aa 8-160) (mouse) (rec.) (untagged) AG-45A-0035YEK-KI01 The antibody fragments are displayedIL 36 (IL 1F6), IL 36 (IL 1F8) and IL 36 (IL 1F9) bind to IL 36R (IL 1Rrp2) and IL 1RAcP, activating similar intracellular signals as IL 1 and are inhibited by IL 36Ra. The expression of IL 36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL 36 family members induce