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Furthermore, ulinastatin is a serine protease inhibitor that inhibits trypsin and is clinically used to treat pancreatitis, disseminated intravascular coagulation, shock, and sepsis [130]

8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo

It is approved only for type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound), and any anti-inflammatory effects observed are considered secondary benefits

Previously, there is study revealed that promoting cellular intake of riboflavin by upregulating expression of SLC52A1 (a riboflavin transporter, also known as GPR172B/RFVT1) plays a crucial role in antisenescence via activating mitochondrial membrane potential and inhibiting the AMPK-p53 pathway [56]

The current cell recruitment strategies are normally based on cytokines or functional peptides which are costly and may cause potential disturbance to subchondral bone homeostasis or lead to cartilage calcification 21