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Kidney Dysfunction: While the kidneys do not directly excrete vitamin B12 efficiently, impaired renal function may lead to elevated serum B12 levels by reducing the clearance of B12-binding proteins or altering their metabolism, thereby contributing to B12 accumulation 8

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After 14 days of treatment, the mice were euthanized via cardiac injection of sodium pentobarbitone given at 35 mg/kg

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Dec 2015;13(12):787-92