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The body relies on a highly coordinated system, primarily driven by the liver, kidneys, and gastrointestinal tract, to neutralize and excrete these substances

Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair

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The absence of IGF-1 pathway activation is also consistently observed across experimental systems, reinforcing its value in studies requiring separation of metabolic and growth-related signaling pathways