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MBP tags can help with solubility issues, but scientists may also choose to add smaller proteins, such as Thioredoxin A (TrxA) that improve disulfide bond formation in order to help keep your protein soluble

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doi: 10.1073/pnas.1803410115, 70

FEMS Immunol Med Microbiol 47(2):167177 Teoh N, Leclercq I, Pena AD, Farrell G (2003) Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning

Another investigation highlighted the link between glutathione deficiency and endothelial dysfunction