In this review, we proposed that there are two main insults that precipitate hyperoxia-induced AKI: (1) dysfunction due to reduced renal blood flow and alteration of the lung-heart-kidney axis, and (2) cellular harm due to inflammation and oxidative stress
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The method utilizes ultrafiltration for sample preconcentration followed by nano-liquid chromatography-high-resolution mass spectrometry (nanoLC-HRMS/MS)
[49] synthesized new variants of HCS peptide MS1, a BIM-based peptide, which was previously engineered to have high affinity and specificity for myeloid cell leukemia-1 (Mcl-1), performing the optimization by iteration steps, and found that the conversion of staple positions is closely related to the specificity of the stapled peptide, while the unmodified template peptide (BIM SAHB A1 ) peptide possessed higher Mcl-1-specificity when the staple was located at the 2e3b position