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[73,74] Other peptides derived from histone proteins have shown similar effects and have been investigated as therapeutic candidates in SLE, [75, 76, 77] including the phosphorylated spliceosomal epitope peptide P140, which represses B cell differentiation and protects against murine lupus

Concerns about IGF-1 include potential effects on cancer risk, acromegalic changes with chronic elevation, and metabolic disruption