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High plasma glucose also promotes OxS by activation of the polyol pathway in which aldose reductase (AR) reduces glucose to sorbitol followed by the conversion of sorbitol to fructose by sorbitol dehydrogenase (SDH)

Health Screening: Undergo necessary medical tests to rule out conditions like liver disease, kidney disease, or asthma, as these may complicate the treatment

Sleep supports mitochondrial restoration through enhanced antioxidant defenses, autophagy, and bioenergetic recovery (Mauri et al., 2022

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)