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The compounds demonstrated different pharmacology in vivo, with TLC-2716 having lower plasma exposures and higher and sustained ileum and liver exposures (due to active uptake into hepatocytes) than TLC-6665 (ratio of AUCs of TLC-2716/TLC-6665 in plasma and liver of 0.17 and 6.24, respectively

Patti M, Christian R, Palokas M