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Due to the mitochondrial double-membrane structure, mitochondrial fusion requires sequential steps involving the OMM and IMM

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

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In brief, its canonical pathway is activated by damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs), which stimulate the assembly of the NLRP3 inflammasome, gasdermin D pore formation, and release of IL-1 and IL-18