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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

They generate singlet oxygen under irradiation which induces cell apoptosis, inhibiting the growth of hepatoma

However, optimizing your timing to maximize protein and nutrient intake (by aligning higher-appetite days with protein-rich meals) can help mitigate this side effect indirectly