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10.1002/ange.201903981 62 WangD.WuH.WangC.GuL.ChenH.JanaD.et al (2021)

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I n skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating this rapid turnover of IRS1, since IRS1 loss can be rescued by knockdown of Fbxo40

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Chronic inflammation may contribute to: Loss of muscle mass Insulin resistance Cognitive decline Cardiovascular disease Decreased mitochondrial function Increased oxidative stress Poor skin health Reduced recovery capacity This is why longevity medicine focuses heavily on reducing inflammatory burden while improving cellular resilience