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Gln, a nonessential amino acid abundant in the bloodstream, along with its metabolites lutamate and ketoglutarate (-KG), serves as a vital source of carbon and nitrogen, providing essential raw materials for the synthesis of nucleotides and amino acids ( Although some Gln metabolic inhibitors have entered clinical trials, the heterogeneity among tumors complicates their effectiveness

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Chronic immobilization stress decreases hippocampal GH expression and impairs hippocampus-dependent behavioral tasks, including contextual fear conditioning (80)

10.1038/mi.2015.32 Mucosal Immunol