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These complexes facilitate the activation of caspase-3/7, cleavage of GSDMD and GSDME, and phosphorylation of MLKL, leading to membrane pore formation and the progression of PANoptosis [39]

Downstream signaling: Elevated GH subsequently influences insulin-like growth factor 1 (IGF-1) production, which is of interest in cellular growth and repair research models

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doi: 10.2337/diabetes.50.1.32 37 FrystykJGrofteTSkjaerbaekCOrskovH