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The identification of optimal CSC-associated targets is difficult as CSCs can switch between a more quiescent state and a proliferative state (69)

For instance, this study (146) utilized a neonatal maternal separation stress model in mice to simulate irritable bowel syndrome (IBS) and identified neuronal nitric oxide synthase (nNOS) as a novel and reliable biomarker for interstitial cells of Cajal stimulation in IBS

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Identifying responders before treatment could improve outcomes and reduce failed treatment attempts

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