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Key determinants of success include nanoscale size optimization, surface charge modulation, and ligand-mediated targeting, which exploit endogenous transport pathways at the bloodbrain barrier

All peptides benefit from refrigeration

doi:10.1530/ETJ-22-0211 [PubMed] 47

The rationale for injectable administration stems from the limitations of topical delivery

Although most irAEs are identified during pre-clinical development, the spectrum, timing and outcomes were only recently investigated through real-world, large-scale pharmacovigilance analyses like the spontaneous reporting systems that looked at the real-time monitoring of these drugs safety profiles [16]