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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

28% des Niois achtent leurs cigarettes en Italie, 42% des ventes chappent aux buralistes Alpes-Maritimes Mais o sont achetes les cigarettes

Despite differences in design intended to lower nicotine yield, the compensatory behaviors exhibited by smokerssuch as deeper inhalation and more frequent smokingresult in nicotine and tar intake levels that are comparable to, or even exceed, those of regular cigarettes

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