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Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity

To circumvent the need for intracellular bioactivation of AQ or DEAQ by CYPs, the toxic effects of the synthetic chemically reactive metabolites AQ-QI and DEAQ-QI were studied

At present, this concept is best framed as a hypothesis-generating interpretation supported mainly by spatial and functional evidence, rather than as a conclusively demonstrated direct organelle interaction

Ahmadi R, Abbasi Z, Asgary V (2015) The effects of acute and chronic immobilization stress and aloe vera extract on serum levels of TSH, T3 and T4 in male rats

Translating this mechanistic understanding to PD pathogenesis, emerging evidence underscores the central role of ferroptosis