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Some people have a much higher chance of developing B12 deficiency, and understanding these risk factors helps us catch problems early

Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Panel on Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Panthothenic Acid, Biotin, and Choline and the Subcommittee on Upp 3

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Methotrexate can cause hepatotoxicity, leading to insufficient drug tolerance (Wang et al., 2018)