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Additionally, HGF/c-Met signaling regulates the NADPH oxidase system, initiating an Nrf2-mediated protective response

Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation

is supported by a Project Grant from the Canadian Institutes for Health Research (CIHR), an End Diabetes Award from Diabetes Canada and a Tier 2 Canada Research Chair (Pharmacotherapy of Energy Metabolism in Obesity)

Retinal extracts Protein extracts were obtained from dissected mouse retinas in RIPA Lysis and Extraction Buffer (Thermo Fisher Scientific, cat