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307,413 In terms of apoptosis inhibition, GLP-1 activates the PI3K/Akt signaling pathway, enhances the expression of the anti-apoptotic protein Bcl-2, and inhibits the activation of caspase family proteins, reducing cell apoptosis

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This oxidative insult has been demonstrated to impair pancreatic -cell function and exacerbate insulin resistance, thereby contributing to the progression of T2DM [310]

Laser lines and filters were set up for the appropriate channels as described in Supplementary Table 7