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How long the injection lasts depends on several factors: How severe the deficiency is A persons age and how fast their body processes things Problems with digestion or absorbing nutrients Daily habits or activity levels How often does the body use B12 inside its cells People with pernicious anemia or ongoing deficiency often get weekly shots, while others do fine with a monthly injection

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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses