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28) and remained unchanged at the studys end (both 27)

10.1080/15548627.2017.1291113 Autophagy 273 YamashitaS

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Thicker needles (29 gauge) draw and inject faster but may cause slightly more discomfort at the injection site

In a Complete Response Letter, the regulator stated that Aldeyras New Drug Application did not demonstrate efficacy in treating ocular symptoms associated with dry eyes and informed the company that at least one additional adequate and well-controlled study would be required to demonstrate efficacy