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The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)

results appear gradually over a course of sessions, revealing healthier and more radiant skin over time

In addition, MLC phosphorylation or activation of other kinases triggers the opening of TJ proteins (including ZO-1 and claudin-1), which can be reversed by adding an inhibitor of MLC phosphorylation [57]

Total chlorophyll and carotenoid contents were calculated following the procedure described by Lichtenthaler and Wellburn 44