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L. I. Fedoreyeva, I. I. Kireev, V. Kh. Khavinson, and B. F. Vanyushin, Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA, Pleiades Publishing Ltd, Nov. 2011. doi: 10.1134/s0006297911110022

In practical terms, that shows up as fatigue that seems disproportionate to your effort, shortness of breath during workouts that used to feel manageable, and a general sense that your body isn't performing the way it should

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