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In advanced COPD, hypoxia plays the primary role in producing pulmonary hypertension, both by causing vasoconstriction of the pulmonary arteries and by promoting remodeling of the vessel wall (either by inducing the release of growth factors 107 or as a consequence of the mechanical stress that results from hypoxic vasoconstriction)

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The study found that teenagers thought white tips and longer cigarettes portrayed a cleaner, feminine image reminiscent of glamorous female stars from old movies

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