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Supplement allocation was implemented using 6-digit randomization codes, with the list generated by an unblinded individual not involved in conducting the study

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Nine children received IGF-1 injections at doses of 150-200 milligrams per kilogram of body weight per day for at least 1 year

In vivo rodent models have explored tissue-specific IGF-1R engagement by comparing the biodistribution and signalling footprint of IGF-1 LR3 against the native 70-amino acid ligand

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