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A study in the Biochemical Journal showed that mice given IGF-1 LR3 experienced a 2.5x degree of anabolic muscle-building effects compared to mice receiving stand-alone IGF-1: The administration of insulin-like growth factor-I (IGF-I) via subcutaneously implanted osmotic pumps partially reversed a catabolic state produced by the co-administration of 20 micrograms of dexamethasone/day to 150 g male rats

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Caspase-4/5/11 can also activate the NLRP3 inflammasome, which subsequently activates caspase-1, resulting in the production and release of IL-1 and IL-18 (Sahoo et al., 2023)