Hence, although future kinetic studies might confirm a random mechanism for the rate-limiting first part of monothiol mechanism (iii) in vitro, GSH is probably the first and the non-glutathione disulfide the second substrate under physiological conditions in vivo (Fig
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Since then, several other genes have been identified as either causative or risk factors for PD, including LRRK2, Parkin, PINK1, DJ-1 , and VPS35 , among others [4]